Sunday Night Football for Week 7 features a non-conference clash between a couple of two-win teams with the Indianapolis Colts visiting the San Francisco 49ers.
San Francisco is still dealing with injury issues coming off a bye but was on the board as a 4.5-point NFL betting favorite for this primetime game. Indianapolis kind of enjoyed a bye of its own, thrashing lowly Houston 31-3 last Sunday for its third straight ATS win and fourth payday in the past five games.
Check out our NFL free picks and predictions for Colts vs. 49ers on Sunday, October 24.